目的 通过试验研究与数值模拟相结合，建立了兔耳增生性瘢痕(HPS)治疗过程中以激光治疗次数为自变量的力学模型，用以评估HPS的临床疗效。方法 利用CO2激光器建立兔耳早期HPS模型，随后进行了连续三次脉冲染料激光 (PDL)联合CO2点阵激光治疗，并在每次治疗恢复后测试HPS的单轴压缩力学性能，用以拟合Ogden超弹性本构模型，得到治疗过程中HPS的力学参数，并通过LM最优化算法建立HPS力学参数与激光治疗次数之间的函数关系。结果 HPS的力学参数随激光治疗次数的增加而增大，并逐渐趋于一个常数，即正常皮肤的力学参数；且随着激光治疗次数的增加，HPS力学参数的增幅逐渐减小，初始增幅为60%，3次治疗后降为4.09%。结论 激光治疗初始疗效最明显，随着症状的减轻，激光单次疗效不再显著。
Objective A mechanical model with the number of laser treatment as the independent variable in the treatment process of rabbit ear hypertrophic scar (HPS) was established by combining experimental research and numerical simulation to evaluate the clinical efficacy of HPS. Methods Firstly, the HPS model of rabbit ear was established by CO2 laser, and then the HPS was treated for continuous three times by pulsed dye laser (PDL) combined with CO2 lattice laser. After each treatment, the uniaxial compression mechanical properties of HPS were tested to fit Ogden hyperelastic model to obtain the mechanical parameters of HPS during the treatment. The functional relationship between the mechanical parameters of HPS and times of laser treatment was established by LM optimization algorithm. Results The mechanical parameters of HPS increased with the increase of laser treatment times, and gradually tend to a constant, that is, the mechanical parameters of normal skin. With the increase of laser treatment times, the growth ratio of HPS mechanical parameters gradually decreased. The initial growth ratio was 60% and decreased to 4.09% after three times of treatment. Conclusions The initial therapeutic effect of laser therapy is the most obvious, and with the relief of symptoms, the effect of single laser therapy is no longer significant.