Objective To analyze the mechanical properties of stent retrievers with different structures and to provide theoretical support for the design and clinical selection of stent retrievers. Methods Three kinds of stent retrievers with different structures (B3, K4, X) were evaluated by finite element analyses and in vitro simulation experiment. The analysis parameters were radial support force, withdrawal force and the thrombosis state during the thrombotomy test. Results The radial supporting forces of the three stent retrievers obtained from the experiment were B3(0.48N), K4(0.43N), X(0.51N), respectively. The larger the crimping size, the greater the radial supporting force of the stent retrievers. The radial support force of the stent increases significantly when the crimping size is larger than 3mm. The simulated thrombus removal experiment results show that the peak values of the three stent are B3(0.410N)＜K4(0.451N)＜X(0.501N). The experimental results are consistent with the results of finite element analysis. Conclusion Both the experimental results and the finite element results show that the X stent has better mechanical properties. This method can be used as an analysis method to evaluate the performance of the stent retrievers, and provide some references for the performance improvement and development of the stent retrievers.