一种模拟血液循环系统实验研究
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哈尔滨工业大学机电工程学院

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An simulation experimental study on mock circulation system
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    摘要:

    目的:研究一种能够准确复现人体血液动力学环境的模拟血液循环系统(Mock Circulation System,MCS)用于心室辅助装置、人工心肺机等人工器官研发过程中的体外测试。 方法:建立了一套包括体、肺循环的双心驱动MCS,基本涵盖了心血管系统的主要生理特征及功能,其中对瓣膜和动脉的模拟提出了采用硅胶材料制作的新方式。该系统可以通过调整控制系统参数或结构参数来模拟正常人体、心衰、瓣膜疾病、动脉硬化以及外周阻性变化等多种生理环境。并利用传感器与控制系统实现压力、流量的实时显示、控制和数据保存。 结果:该MCS模拟正常人体和多种病症下的血液动力学环境均与人体实际情况基本一致。并且新的瓣膜和动脉的模拟方式减小了压力波动,使模拟效果更好。在模拟心衰病症下使航天泰心HeartCon型心室辅助装置(VAD)接入系统,可以看到其血液动力学环境(主动脉压力、左心房压力、心排量等)均能恢复到正常范围。 结论:该MCS能够准确的复现多种生理状态下体、肺循环的血液动力学环境,为心室辅助装置等人工器官的性能测试和控制策略的设计提供了有效的实验平台。同时,采用硅胶材料制作瓣膜和动脉的模拟方式也可以作为MCS中新的研究思路进一步完善。

    Abstract:

    Purpose: A mock circulation system (MCS) which can accurately reproduce the human hemodynamic environment is studied for in vitro testing in the development of artificial organs such as ventricular assist devices and artificial heart-lung machine. Method: A double-heart MCS including the systemic and pulmonary circulation is established, which basically covers the main physiological characteristics and functions of the cardiovascular system. The simulation of valves and arteries are proposed with a new way made of silicone material. The MCS can simulate a variety of physiological environments such as normal human body, heart failure, valvular disease, arteriosclerosis and peripheral obstruction changes by adjusting the control system parameters or structural parameters.The sensor and control system are used to realize the real-time display, control and data preservation of pressure and flow. Result: The MCS simulates the hemodynamic environment of the normal human body and a variety of diseases, which are basically consistent with the actual human condition. And the new valve and artery model reduces pressure fluctuations in a much better way. The first-generation ventricular assist device (VAD) is connected to the experimental platform with heart failure simulated, and the hemodynamic environment (aortic pressure, left atrial pressure, cardiac output, etc.) could all be recovered to the normal range. Conclusion: The MCS can accurately reproduce the hemodynamic environment of body and pulmonary circulation in a variety of physiological states. It provides an effective experimental platform for the performance test and control strategy design of artificial organs such as ventricular assist device. At the same time, the simulation method of making valves and arteries with silicone material can also be further improved in MCS.

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  • 收稿日期:2021-06-03
  • 最后修改日期:2021-07-06
  • 录用日期:2021-07-15
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