Micro-PIV在生物医学工程领域的研究进展
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1.上海健康医学院协同科研中心;2.上海健康医学院医疗器械学院

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Research Progress of Micro-PIV in Biomedical Engineering Field
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    摘要:

    血液是生物体内重要组成部分,肩负着物质输送和传递的任务。血流微环境影响着心血管发育、红细胞聚集及血液黏度、癌症转移和动脉粥样硬化等生理病理过程,在药物输送、细胞分选、人工器官设计和生物体运动等研究领域,流场环境也起到重要作用,这使得微流场的测量和定量分析变得尤为重要。Micro-PIV将传统的粒子图像测速和显微技术结合起来,通过对高速相机在不同时刻拍摄的两组图像进行互相关分析,能够计算得到微流场环境的速度场。与其他速度测量方法相比,Micro-PIV技术具有较高的时间分辨率和空间分辨率。本文介绍了Micro-PIV系统的主要组成及相关原理和分析方法,并总结了其近年来在生物医学工程领域的研究进展,并就其不足和应用前景展望进行了探讨。

    Abstract:

    Blood is an important component of living organism which is responsible for material transportation. The microenvironment of blood flow plays an important role in physiological and pathological processes like angiogenesis and cardiac development, erythrocytes aggregation and blood viscosity, tumor metastasis and arteriosclerosis. Besides, micro-fluid environment significantly affects drug delivery, cell screening, and artificial organ design. Thus, the measurement and quantitative analysis of micro-fluid contribute to the biomedical engineering filed. Micro-PIV combines conventional particle imaging velocimetry (PIV) and microscopy technique to successfully measure the velocity profile in micro fluid in the way of analyzing two group of images at different time interval by correlation method. Comparing with other velocity measurement methods, Micro-PIV has high temporal resolution and spatial resolution. In this paper, we introduced the main setup of Micro-PIV and its principle analysis method. Recent studies of Micro-PIV applications in biomedical engineering field were then reviewed. Moreover, the drawbacks and future applications of Micro-PIV technique were discussed.

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历史
  • 收稿日期:2021-06-02
  • 最后修改日期:2021-07-30
  • 录用日期:2021-08-03
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