Objective To compare the effects of hip abductor fatigue on postural stability and its neuromuscular control group by sex during single-leg side-jump landing. Methods Twenty male and Twenty female adults were required to execute single-leg side-jump landing before and after hip abductor fatigue protocol. The center of pressure, ground reaction force, lower extremity kinematics, joint moment, muscle activity were compared. Results The max displacements and velocities of COP decreased after fatigue both in male and female. The peak angle of hip abduction and ankle eversion increased after fatigue. The peak torque of ankle inversion increased after fatigue. The peak torque of ankle plantar flexion was higher in male than in female. At the 200-ms pre-landing, the RMS of rectus femoris, biceps femoris, tibialis anterior, peroneus longus were lower in male than in female. At the 200-ms post-landing, the RMS of biceps femoris in male was lower than in female, and the RMS of TA increased in male after fatigue. Conclusions The postural stability in frontal plane decreased after hip abductor fatigue. The frontal plane control of ankle joint was weakened. Anticipatory postural adjustments strategy was stronger in female than in male. It was worth further exploring the sex difference in mechanism of lower extremity joint injuries.