Objective To study the influence of skull thickness on intracranial biomechanical parameters by finite element method. Methods The female head at 5th percentile was selected for CT scanning to construct finite element model of the head with high biofidelity,and the model was verified by reconstructed cadaver test. The finite element model of the head with different skull thickness was established, and multiple groups of tests were carried out to compare the intracranial mechanical parameters. Results The negative value of intracranial pressure was significantly affected by the decrease in skull thickness under the same head size, while the negative value of intracranial pressure was slightly affected, with an increasing trend. The shear stress and von Mises stress of brain tissues were significantly increased with skull thickness increasing. Conclusions Under the same head size, the skull thickness will affect head injury to a certain extent, and people with small skull thickness are more likely to be injured than those with large skull thickness.