3D打印高度可调聚醚醚酮颈椎椎间融合器的优化设计与评价
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基金项目:国家重点研发计划项目(2018YFE0207900),自然科学基金重点项目(51835010),广东省重点领域研发计划项目(2018B090906001),国家重点研发计划项目(2018YFB1107000),中央高校基本科研业务费,陕西省青年创新团队,军事提升项目(2016TSB-005)


Optimization Design and Evaluation of Three-Dimensional Printed PEEK Cervical Interbody Fusion Cage with Adjustable Height
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    摘要:

    目的 针对传统颈椎融合器与患者解剖形貌匹配程度较低的临床问题,建立一款具备高度调节功能且外形与椎体相匹配的颈椎融合器,并对其生物力学性能进行评价。方法 按照颈椎前路解压术(anterior cervical discectomy and fusion,ACDF)建立颈椎C4~5节段融合模型,模拟前屈、后伸、左右侧弯、左右旋转不同运动工况,计算融合器与椎体终板的应力。3D打印制备融合器后进行体外力学实验,探究融合器的安全性与稳定性。结果 该融合器可保持融合C4~5节段颈椎活动度(range of motion, ROM)为1°~2.8°,降低至自然节段ROM的40%~80%。在体外压缩试验中,融合器屈服载荷为(2 721.67±209) N,满足服役状态下生理载荷的最大需求。结论 所设计的高度可调融合器显示出较优的生物力学性能,且可以减少手术中的选型步骤。

    Abstract:

    Objective Aiming at the clinical problem of the low matching degree with the patient’s anatomical morphology for traditional cervical fusion cage, a cervical fusion cage with the function of adjustable height and the shape matched with the vertebral body was established, and its biomechanical properties were evaluated. Methods A cervical C4-5 segment fusion model was established according to anterior cervical discectomy and fusion (ACDF), so as to simulate different motion conditions, i.e. anterior flexion, posterior extension, left/right lateral flexion, left/right rotation, and stress of the fusion cage and vertebral endplate was calculated. After three-dimensional (3D) printing of the fusion cage, an in vitro mechanical experiment was conducted to explore safety and stability of the fusion cage. ResultsThe fusion cage could keep the range of motion (ROM) of cervical vertebrae at the fusion segment with 1°-2.8° and reduce the ROM to 40%-80% of the natural segment. In the in vitro compression test, the yield load of the fusion cage was (2 721.67±209) N, which met the maximum demand of the physiological load in service state. Conclusions The designed fusion device with adjustable height shows better biomechanical properties and can reduce the selection step in operation.

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张童童,董恩纯,郑纪豹,李涤尘,康建峰,石磊,王玲.3D打印高度可调聚醚醚酮颈椎椎间融合器的优化设计与评价[J].医用生物力学,2021,36(2):177-183

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  • 收稿日期:2020-09-15
  • 最后修改日期:2020-10-27
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  • 在线发布日期: 2021-04-25
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