微血管模型的重建和生物力学设计
DOI:
作者:
作者单位:

北京航空航天大学

作者简介:

通讯作者:

中图分类号:

基金项目:


Reconstruction and biomechanical design of microvascular models
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    血管生成在许多生理和病理过程中发挥着重要作用,但其机理仍不清楚。由于血管细胞在体内同时受到多种生物化学和生物力学刺激,处于复杂的微环境中,因此在体外构建血管模型并重现其在体微环境,对探究血管生成机制十分必要。近年来,随着微加工和微流控技术的进步,各种体外微血管模型应运而生,对剪切力、渗流、血管生成因子浓度梯度等变量进行了准确控制,极大地推动了血管生成的研究。本文拟对各类微血管模型的构建方式、发展演化及其生物力学设计作一综述。

    Abstract:

    Neovascularization plays an important role in many physiological and pathological processes, but its mechanism is still unclear. Since vascular cells are subjected to a variety of biochemical and biomechanical stimulations in vivo and live in a complex microenvironment, it is necessary to construct the vascular model in vitro and mimic the in vivo microenvironment to explore the mechanism of neovascularization. Recently, owing to the advance of micromachining and microfluidic technology, various in vitro microvascular models have emerged. Variables such as shear stress, interstitial flow and biochemical gradient of angiogenic factors have been controlled in these models, which greatly promotes the research of neovascularization. Here, the construction, development and biomechanical design of various microvascular models are reviewed.

    参考文献
    相似文献
    引证文献
引用本文
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2020-12-21
  • 最后修改日期:2021-03-09
  • 录用日期:2021-03-09
  • 在线发布日期:
  • 出版日期: