Objective：Taking ovariectomized rats as the research object, the effects of moderate intensity exercise training combined with Xianlinggubao Capsule on bone mineral density, bone metabolism and femoral biomechanics of ovariectomized rats were observed.Methods：Fifty female SD rats were randomly divided into 5 groups: group A was the normal control; group B was given 1ml normal saline by gavage after ovariectomy for one week; group C was given moderate intensity exercise training (exercise speed was 20m / min, lasting for 60min per day, continuous 5D / week); group D was given Xianlinggubao capsule [0.4g / (kg · d)] 1ml after ovariectomy, and group E was ovariectomized for 1 week Four weeks later, Xianlinggubao capsule (1ml) and moderate intensity exercise training were given by gavage, with 10 rats in each group. After 8 weeks of continuous treatment, blood biochemical indexes, bone mineral density (BMD), micro CT and biomechanics of femur and L5 vertebral body were detected.Results：Compared with group B, the concentrations of BALP, PINP and osteocalcin in group C ~ e were significantly increased (P < 0.05), and the concentrations of serum calcium, β - CTX and tracp-5b were significantly decreased (P < 0.05); compared with group C and D, the concentrations of BALP, PINP and osteocalcin in Group E were significantly increased (P < 0.05), and the concentrations of serum calcium, β - CTX and tracp-5b were significantly decreased (P < 0.05). Compared with group B, the BMD of L5 vertebral body and femur in group C ~ E was significantly increased (P < 0.05); compared with group C and D, the BMD of L5 vertebral body and femur in Group E was significantly increased (P < 0.05). Compared with group B, the bone volume fraction, trabecular number and trabecular thickness of femur (or L5 vertebral body) in group C ~ E were significantly increased (P < 0.05), and the trabecular space and structural model index were significantly decreased (P < 0.05); compared with group C and D, the bone volume fraction, trabecular number and trabecular thickness of femur (or L5 vertebral body) in Group E were significantly increased (P < 0.05), and the trabecular space and structural model index were significantly decreased (P < 0.05) .05)。 Compared with group B, the maximum load, maximum deflection and maximum stress of L5 vertebral body in group C ~ E were significantly increased (P < 0.05); compared with group C and D, the maximum load, maximum deflection and maximum stress of L5 vertebral body in Group E were significantly increased (P < 0.05). Compared with group B, the maximum load, elastic load, elastic deflection, elastic modulus, elastic stress, maximum stress and elastic deflection of femur in group C ~ E were significantly increased (P < 0.05); compared with group C and D, the maximum load, elastic load, elastic deflection, elastic modulus, elastic stress, maximum stress and elastic deflection of femur in Group E were significantly increased (P < 0.05).Conclusion：Moderate intensity exercise training combined with Xianlinggubao capsule can improve bone mineral density, bone metabolism and bone microstructure, and improve bone mechanical properties of ovariectomized rats.