Abstract: Objective: The aim is to construct an individualized fluid-solid coupling model, calculate and analyze the influence of different blood characteristics on the hemodynamics in the aneurysm cavity, and further explore the influence on the rupture of cerebral aneurysm.. MethodsFirst, 3D digital silhouette images are collected to construct an aneurysm model, and the influence of different blood flow characteristics on the dynamic parameters of carotid aneurysm is analyzed by the fluid dynamic calculation method (CFD) under the same boundary conditions. Finally, a PIV experiment was performed on the simplified carotid aneurysm experimental model to verify the reliability of the blood flow calculation method.Results The fluid-structure coupling model with different blood flow characteristics, within a cardiac cycle, at the same time, there are big differences in the area of low velocity area in the tumor cavity, the streamline distribution of the tumor cavity, WSS and the deformation of the aneurysm wall. Through experiments, it is found that the position of the vortex in the tumor cavity changes with the speed, which is consistent with the flow trend of the simulation analysis result. Conclusion The two kinds of blood characteristics are less different, but the non-Newtonian fluid is closer to the true state of blood, and the numerical result will be closer to the true flow state.