Abstract:Objective A three-dimensional solid model of medulla oblongata-superior cervical spinal cord with fine gray matter nucleus and white matter fiber bundle dividing line based on specimen pathological section data was established, and the stress and strain levels of medulla oblongata-superior cervical spinal cord under dentate process compression were obtained by finite element analysis to provide reference for clinical research. Methods Mimics is used to process the slice data to establish the point cloud model; SolidWorks is used to locate, edit and optimize the point cloud model to establish a three-dimensional solid model; HyperMesh is used to establish the finite element model and ANSYS is used for finite element analysis. Results A medulla oblongata-superior cervical spinal cord model with clear boundary between gray matter and white matter and white matter fiber bundle was established, and the stress and strain levels and stress-strain contrast curves of white matter and gray matter under different compression degrees were obtained. Conclusions Combined with pathological sections of specimens and reverse engineering, a three-dimensional medulla oblongata-superior cervical spinal cord model with clear morphology and structure of gray matter and white matter can be established; when the medulla oblongata-superior cervical spinal cord is compressed, the stress level of gray matter is less than that of white matter, and about 20% of the degree of compression is the critical state of white matter. when the disease develops beyond the critical state, the biomechanical properties of white matter may fail, resulting in gray matter damage.