Abstract:Biliary stent is an effective method for malignant biliary obstruction. However, duodenobiliary reflux is common after conventional stent, which causes complications such as biliary retrograde infection and stent blockage, and seriously reduces the quality of patients’ life. At present, anti-reflux biliary stent is considered as a promising palliative treatment method that takes into account drainage and preventing duodenobiliary reflux. In this paper, research status of anti-reflux biliary stent was reviewed, and focus on key problems such as design and evaluation of anti-reflux valve, valve and stent connection design, biomechanical analysis of anti-reflux biliary stent. The current research progress and trend of anti-reflux biliary stent were summarized and analyzed.