帕金森病静止性震颤机理的模型仿真
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Model Simulation of the Resting Tremor Mechanism in Parkinson’s Disease
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    摘要:

    目的 研究帕金森病静止性震颤特征与人体反应迟缓的内在联系。方法 结合上肢腕关节的动力学建模,研究腕关节内外翻方向自由度运动特征。引入人体自主控制环节,以控制系统的时滞概念模拟帕金森患者反应延迟特性,进行人体腕关节不自主运动的稳定性分析和动力学响应。结果 通过时滞系统稳定性分析和数值求解,发现当反应延迟一定程度时,帕金森患者的腕关节将发生不自主震颤,与帕金森患者静止性震颤病症契合。结论 帕金森病静止性震颤属于神经系统感觉和动作延迟引起。

    Abstract:

    Objective To study the internal relationship between resting tremor and slow response in patients with Parkinson’s disease. Methods The movement characteristics of wrist joints in valgus direction was studied by dynamic modeling on wrist joints of the upper limbs. The system delay concept was introduced with human autonomous control and the sensory delay characteristics of Parkinson’s patients was simulated, to make stability analysis and dynamic response of the involuntary wrist movement. Results The stability analysis and numerical solution of this time-delayed control system showed that when the sensation was delayed to a certain extent, involuntary tremor of wrist joints in patients with Parkinson’s disease would happen, which conformed to resting tremor from Parkinson’s disease. Conclusions Resting tremor from Parkinson’s disease is caused by sensation and movement delay.

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罗银淼,詹倩,邵静松.帕金森病静止性震颤机理的模型仿真[J].医用生物力学,2020,35(2):235-239

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  • 收稿日期:2019-01-03
  • 最后修改日期:2019-03-04
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  • 在线发布日期: 2020-04-27
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