1.Department of Applied Mechanics and Engineering, Sun Yat-sen University, Guangzhou, China;2.Department of Applied Mechanics and Engineering, Sun Yat-sen University;3.The First Affiliated Hospital, Sun Yat-sen University Guangzhou, China
目的：建立一套物理模型实验和数值模拟相结合的综合方法，用于研究上呼吸道气流状态； 方法：本文基于网上公开CT医学图像，重建人体上呼吸道三维模型。基于3D打印技术，建立了上呼吸道实验模型，进行了呼吸的流量过程测量实验；通过对上呼吸道三维模型进行网格划分，采用湍流Realizable k-数值模型，建立了适用于数值模拟模型； 结果：首先进行了与实验工况相应的数值模拟对比研究，得到了与实验吻合的结果。进一步，观察到呼吸过程中的气流呈抛物线形状，呼吸交换过程中上下鼻道有空气残留，另外通过压力场变化和涡结构分布情况可了解到鼻腔内易受刺激区域； 结论：本文提出的方法，充分发挥了物理实验可靠和数值模拟精细的优点，适用于不同的呼吸道问题的研究，对临床个性化医疗具有价值。
Objective: To establish a comprehensive method combining physical model experiment and numerical simulation for studying airflow state of upper respiratory tract.#$NLMethods: Based on CT medical images published online, a 3d model of human upper respiratory tract was reconstructed. Based on 3D printing technology, an experimental model of the upper respiratory tract was established and the flow process of respiration was measured. And a numerical simulation model was created based on the meshing of upper respiratory tract model, and the turbulent realizable k-e model.#$NLResults: First, the numerical simulation was compared with the experimental conditions, and the results were consistent with the experimental results. Furthermore, the airflow in the respiratory process was observed to be in a parabolic shape, and there were air residues in the upper and lower nasal passages during the respiratory exchange process. In addition, the stimulated easily areas in the nasal cavity could be known through the changes in the pressure field and the distribution of vortex structure.#$NLConclusion: The method proposed in this paper, gives full play to the advantages of reliable physical experiments and fine numerical simulation, which is suitable for the study of different respiratory problems, and has application value for clinical personalized medicine.