目的 探究螺钉布局方式对骨愈合的影响，为相关的骨折治疗提供基础。方法 采用有限元方法研究不同螺钉布局方式下骨愈合过程；采用骨折块应变理论（interfragmentary strain theory, IFS）模拟骨痂的生长变化过程；利用Python语言对ABAQUS进行二次开发，使得迭代过程中骨痂所划分的每个单元都根据IFS理论更新弹性模量，从而模拟骨折愈合过程。结果 不同数量螺钉对骨愈合过程的影响小于不同接骨板工作长度对骨愈合过程的影响；稳定固定的前提下，接骨板工作长度一定时，螺钉数量变化对接骨板或螺钉的应力影响较小；接骨板工作长度不同，对接骨板及螺钉的应力影响较大，且工作长度变化对螺钉上应力变化的影响大于对接骨板的影响。结论 相较于螺钉数量，对于接骨板工作的长度应着重考虑，应当遵循在保证内固定系统稳定的前提下，减少接骨板上的螺钉数量，并对接骨板工作长度的选择进行恰当的选择。

Objective To explore the effects of screw configurations on bone healing, so as to provide the basis for related fracture treatment. Methods The process of bone healing under different screw configurations was studied by finite element method, and the change in the process of callus growth during healing periods was simulated by interfragmentary strain theory (IFS). The iterative process for renewing callus modulus in every finite element was conducted by the second-developed ABAQUS based on Python scripting language, thus the process of fracture healing was simulated. Results The effect from different numbers of screws on bone healing was smaller than that from different working length of bone plates. On the premise of stable fixation, given the certain working length of bone plates, the effect from different screw numbers on stress distributions in plates or screws was relatively small, while the effect from different working length on stress distributions in plates or screws was relatively large, and the stress distribution in plates was larger than that in screws at different working length. Conclusions It is necessary to take more consideration on working length of bone plates than the number of screws when they are under a stable fixed situation, and it is a wise choice to reduce the screw numbers and choose a suitable working length for bone healing process.

中央高校基本科研业务费专项基金资助项目（2017B674X14,2016B49614），江苏省研究生科研与实践创新计划项目（KYCX17-0533,KYLX16-0708），江苏省科技成果转化专项资金项目（BA2012061）