Objective To construct a three-dimensional finite element model of human skull with anatomic structure and to study biomechanical responses of the head under various loading conditions. Methods The finite element model of high-precision human head with anatomic structure was reconstructed with the constitutive skull made from elastic-plastic material to simulate the fracture. This model was used to simulate frontal impact intracranial pressure testing, dynamic skull fracture testing and head drop testing reported by the literature, and the simulation reproduced the experimental process of head subjected to impact loads, skull fractures, and biomechanical responses of head fall at different speed. Results Under frontal impact loading, the model showed hedge-side positive-negative intracranial pressure distributions, and the occipital deformation was more serious than that in prefrontal, parietal under similar loading. The faster falling speed would cause more serious injuries. Conclusions To establish the accurate anatomic finite element model of human head can preferably simulate biomechanical responses of the head under the loading of impact and fall. Through quantifying parameters such as contact force and intracranial pressure, injury risks can be assessed to provide scientific references for design of protective devices.