Objective To investigate the coupling relationship between microcirculation loads and other arterial structure, so as to build a reasonable hemodynamic model. Methods Based on the two-way fluid-structure interaction hemodynamic model, a three-way fluid-structure-microcirculation load interaction hemodynamic model was built by considering the influence of microcirculation loads. Four cases were calculated according to different load and elastic modulus. The inlet condition was set as transient single pulse velocity inlet, and the outlet condition was set as free exit. Results The blood pressure always maintained within 80-120 mmHg (1 mmHg= 0.133 kPa) in the whole flow field. The diastolic pressure was finally raised to physiological blood pressure by increasing the total amount of the stored flow. With the increase of elastic modulus in vascular wall, the blood pressure maintained within 65-140 mmHg. With the increase of microcirculation resistance, the blood pressure maintained within 128-166 mmHg. Microcirculation load impeded the flow and reallocated the pressure in the artery. Conclusions It is necessary to consider the influence of microcirculation loads for construction of the hemodynamic model, which has an important clinical significance in analyzing pathogenesis of the circulatory system diseases.