There is an emerging and continuous interest in research about influence of biomechanics on repair and regulation of tissue injury. The development of tissue repair and regenerative medicine provides a new platform for biomechanical research, and biomechanics plays an important role in promoting the development of tissue repair and regenerative medicine. The papers published in special issue of biomechanics and tissue repair in Journal of Medical Biomechanics (Issue No. 5, 2016) were briefly analyzed and reviewed, and the researches in this field were also reviewed and prospected.