Inflammasome is a kind of multi-protein complexes which can mediate the release of several inflammatory cytokines such as IL-1β and thus plays an important role in the occurrence and development of inflammation. Along with the progressive researches on inflammasomes, recent literature has reported that inflammasomes might participate in some inflammatory diseases induced by mechanical forces. Meanwhile, recent studies have shown that mechanical forces can induce inflammation in periodontium, with the expression of IL-1β and caspase-1/-5. However, the role of inflammasomes and related proteins in periodontal inflammation has not been specified so far. In this article, the recent advances on characteristics of inflammasomes and their role in inflammatory diseases related to forces, as well as periodontal inflammation induced by mechanical forces and its relationship with inflammasomes and related proteins were reviewed.