Invisible appliance technology is the latest product resulting from image processing, computer-aided design and rapid prototyping technology in the field of orthodontics, and its development conforms to people’s pursuit for clinical treatment with modern concept of being beautiful, comfortable and healthy. The invisible appliance technology now has been widely used for treating different types of clinical orthodontic malocclusions by doctors, but researches on its clinical efficacy, biological and biomechanical mechanism still show quite deficiency. In this paper, the progresses of biomechanical research on invisible appliance technology were reviewed with the purpose to provide theoretical references for the reasonable, scientific and effective application of invisible appliance technology in clinic.