Objective Try to design a novel axillary crutch with the feature of simple structure, nice appearance, and strong practicality, so as to overcome shortcomings for the past crutches. Methods Based on the methods of modular design and flexible design, an innovative design for axillary crutches was proposed from the aspect of human biomechanics, ergonomics, and industrial design as well. Results The feasibility and clinical applicability of the design were verified by mechanical analysis, finite element analysis, quality inspection of the prototype and preliminary clinical use. Conclusions The novel axillary crutch as the result of the research and design in this study is of great clinical significance. It can effectively reduce the force of wrist and axillary for users, and cut down the occurrence of the secondary damage. Also this study can provide a useful reference for design of other similar crutches.