目的 利用强迫振荡技术（forced oscillation technique, FOT）测量成年哮喘病人和健康人的呼吸道阻力，从而验证该技术对哮喘病诊断的意义。方法 采用手持式FOT仪器分别测量5个哮喘病人和5个健康人的气道阻力，并对其随时间变化的差异进行统计分析。结果基于FOT测量的气道阻力总是随时间呈周期性变化；哮喘病人和健康人受试者的呼吸道阻力分别为(294.98±86.24)、(151.9±39.20) Pa?s/L，两者存在明显差异。结论 FOT测试所得的哮喘病人的呼吸道阻力和呼吸道阻力可变性均明显高于正常人，这与临床常规诊断的结果一致，从而为临床检测呼吸系统动力学参数提供了一种新方法，为准确诊断哮喘病等肺功能异常提供了重要依据。

Objective To validate the significance of forced oscillation technique (FOT) for diagnosis of asthma by using it to measure respiratory resistance of adult asthma patients and healthy subjects. Methods Respiratory resistance was measured by a hand-held FOT device for 5 adult asthma patients and 5 adult healthy subjects, respectively. The variation of respiratory resistance with time was also compared by statistical analysis. Results The respiratory resistance measured by FOT varied periodically with time in all cases, with the respiratory resistance for asthma patients was (294.98±86.24) and for the healthy subjects was (151.9±39.20) Pa?s/L, respectively, showing significant differences in two groups. Conclusions FOT measurement results showed that asthma patients exhibited a greater magnitude and variability of respiratory resistance as compared to their healthy counterparts, which was in agreement with the conventional diagnosis. FOT can provide a novel method for detecting mechanical parameters of the respiratory system in clinic, and as an important reference particularly for the accurate diagnosis of lung dysfunction, such as asthma.

国家自然科学基金资助项目（11172340），中央高校基本科研业务费资助（CDJXS11230022)，重庆市科委百名杰出科技领导人才培养计划,重庆市自然科学基金计划重点项目（CSTC,2010BA5001），重庆大学大型仪器设备开放基金(2010063057,2011063048,20110630,49)