目的 在考虑血管壁弹性条件下，分析颈内动脉血液流动和壁面切应力的分布特性，探讨动脉瘤破裂的生物力学因素。方法 依据二维医学扫描图像构建三维个性化颈内动脉瘤模型。依据人体生理统计数据构建出血管壁模型。根据人体颈内动脉生理流动条件，利用有限体积法和有限元法模拟分析流固耦合作用下颈内动脉瘤中的血流动力学。结果 在动脉瘤腔中有一个明显的涡旋存在，此涡旋流动的方向在心动周期内没有改变；在动脉瘤颈和动脉瘤壁面处存在一个壁面切应力值相对较大区域；在动脉瘤颈和动脉瘤顶有两个区域的Von Mises 应力处于局部最大值。从材料强度角度考虑，这几个区域都是动脉瘤容易破裂的地方。结论 通过流固耦合计算可以获得血管壁面应力分布特性，进而推断动脉瘤破裂的可能位置。

Objective To analyze the distribution characteristics of blood flow and wall shear stress with the consideration of elasticity of the artery wall and to investigate the biomechanical factors inducing aneurismal rupture. Methods The three-dimensional patient-specific internal carotid artery aneurysm model was constructed based on two-dimensional medical scan images. The artery wall model was created based on the statistical data of human body. According to the condition of the pulsatile blood flow in human body, hemodynamics in internal carotid aneurysm with fluid structure interaction was simulated using finite volume method and finite element method. Results An obvious vortex flow in aneurismal cavity was found with the direction unchanged during a cardiac cycle. There was a region at the aneurismal neck and aneurismal dome where the value of wall shear stress was relatively high. It also found two regions in the aneurismal neck and the aneurismal dome where the value of Von Mises Stress reached the maximum locally. In view of the material strength, it should be easy to have aneurismal rupture in these areas. Conclusions The distribution characteristics of vascular wall stress can be obtained by the calculation of fluid structure interaction to further predict the possible position of aneurismal rupture.

国家自然科学基金资助项目（10972016,81171107），北京市自然科学基金资助项目（3092004），北京联合大学校级自然科学基金资助项目（11104541903）