孔隙率对多孔镍钛合金力学性能及离子析出量的影响
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国家自然科学基金资助项目(50671037)


Effect of different porosities on mechanical properties and ion release of porous NiTi alloy
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    摘要:

    目的 筛选生物力学相容性优良的颌骨内植入用多孔镍钛合金,比较二氧化钛(TiO2)与羟基磷灰石(HA)涂层后的镍离子析出量。方法 采用粉末冶金法制备多孔镍钛合金,用金相显微镜观察孔隙形貌,进行压缩与抗折破坏实验,记录其弹性模量与断裂强度值;采用溶胶 凝胶法分别涂覆TiO2与HA涂层,测定1、3、7、15 d镍离子析出量。结果 孔隙由相互连通的50~200 μm大孔和~50 μm微孔组成,孔隙率为(23.5±5.24)%~(38.8±1.82)%;弹性模量为(9.55±0.19)~(4.28±0.32) GPa,断裂强度值为(133±6.75)~(80.5±5.58) MPa。 表面涂层组与未涂层组比较,离子析出量显著降低;氧化钛与羟基磷灰石涂层组间差异无统计学意义。结论 随造孔剂增加,孔隙率增大,多孔镍钛合金的力学性能呈下降趋势;涂层能有效抑制多孔镍钛材料中镍离子析出。

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    Objective To prepare the porous NiTi alloy with good biocompatibility for jaw bone implantation and compare the amount of the nickel ion release from NiTi alloy with TiO2 or HA coatings, respectively. Methods The porous NiTi samples were fabricated by powder metallurgy and the morphological characteristics were observed by metallographic microscope and X ray dispersive spectroscopy (XRD). The elastic modulus and fracture strength of the porous NiTi samples were recorded after the compression test. By sol-gel method, TiO2 or HA coatings were obtained on the porous NiTi samples, and the amount of nickel ion release from the samples was measured at 1,3,7,15 d, respectively. Results The pores were interconnected with the pore size of 50~200 μm and ~50 μm. The porosities of porous NiTi samples ranged from (23.5±5.24)% to (38.8±1.82)%, the elastic modulus from (9.55±0.19) GPa to (4.28±0.32) GPa, the fracture strength from (133±6.75) MPa to (80.5±5.58) MPa (P<0.05). The amount of nickel ion release from porous NiTi samples with HA or TiO2 coatings were obviously lower than that of porous NiTi samples uncoated. There were no statistic differences between HA-coating group and TiO2-coating group(P>0.05). Conclusions The mechanical properties of porous NiTi alloy declined with the increase of pore-forming agent and porosity. Coating treatment could effectively inhibit the release of nickel ion from the porous NiTi alloy.

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徐玮,石新莹,关锐峰,张新平,赵克.孔隙率对多孔镍钛合金力学性能及离子析出量的影响[J].医用生物力学,2011,26(4):349-354

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  • 收稿日期:2011-02-10
  • 最后修改日期:2011-03-23
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