壁冠状动脉血流动力学特性的实验模拟与理论研究
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上海市重点学科建设项目资助(P0502); 上海市高等学校科学技术发展基金项目(05EB07)


Theoretical calculation and experimental research of hemodynamics characteristic of mural coronary artery
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    摘要:

    目的临床研究、动物实验和模拟试验都证实心肌桥在收缩期的压迫作用,可引起壁冠状动脉管腔狭窄,从而使流量、流速及压力发生变化,导致血流动力学特性的异常现象。作者从"水击"理沦的角度探讨冠状动脉心肌桥前端的压力和流速变化这一异常现象的力学背景。方法利用心肌桥模拟装置在收缩期中和舒张期初"水击"发生前后对壁冠状动脉血流动力学进行模拟并用一维水击波理论模型进行分析、计算,与正常情况下实验数据对比分析。结果壁冠状动脉近端收缩压的升高幅度、舒张期流速的升高幅度计算值与实验值基本一致。结论证实了壁冠状动脉血流动力学特性异常现象是由扰动引起的"水击"波。

    Abstract:

    Objective Clinical research,animal and simulation experiments have revealed that the myocardial bridge presses mural coronary artery,which leads to the changes of the rate of flow and pressures of mural coronary artery, and results in special homodynamic phenomenon.This paper discusses the mechanism of this phenomenon in the proximal part of the myocardial bridge using water hammer theory.Methods The hemodynamical characteristics of mural coronary artery were simulated using a simulated apparatus.The pressures and velocities in the proximal part of the myocardial bridge were measured in middle of systole and at the beginning of diastole.One-dimensional water hammer theory was used and compared with the data of experiments.Results Theoretical elevates of systolic pressures and diastolic velocities of the mural coronary artery basically agree with the data of measurements.Conclusion The mechanical mechanism of special phenomenon of mural coronary artery can be explained using water hammer theory.

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丁皓,刘永,沈力行,张国辉,王克强.壁冠状动脉血流动力学特性的实验模拟与理论研究[J].医用生物力学,2007,22(3):251-254

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