Objective Employing a new coupling method of left ventricle-systemic circulation to test the hypothes the hypothesisi that times of the beginning (t1) and end (t2) of systole are not the parameters but the results of coupling through which pressure and flow in artery are affected. Methods Arterial properties are estimated with a nine elements windkessel model. Left ventricle is simulated by E(t) model. Then they are coupled under the t1,t2-included principle of least cardiac work. Results This new method shows some improvement to improvments to approach the experimental results of the blood pressure and flow. The t1,t2-included mechanism can well interpret the changes in pressure and flow corresponding to the changes of other parameters. Conclusion t1,t2 should be the results of coupling and they play important roles in coupling between heart and artery.