This work was aimed to observe,using the in vitro experimental model,the role of calcium in injury process of the cultured hepatic cells(HCs) wounded by the pressure waves derived from high vclocity projectiles(HVP).The results showed that the HCs can be injured and its injury:severity was partiallay related to the increment of the intracellular calceium,The higher the values of the pressure waves,the severer the damage of HCs.The cellular impairments can be alleviated to some extent by pretreaitng the HCs with calcium antagonist diltiazem.